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• Intelligent control command and task execution with obstacle avoidance, fault-detection
and diagnosis as a basis for reconfigurable control and re-planning of path and missions
will be targeted.
Centre of Molecular lnflammation Research {CEMIR) at
NTNU
Foredrag på NTVA-møte i Trondheim 16. april2013
Terje Espevik, professor, NTNU
http://www.ntnu.edu/cemirVision
The vision of CEMlR is to lay the foundation for identifying new therapeutic targets and
developing new diagnostic tools for inflarnrnatory diseases through an integrated l O-year
program of research and research training in molecular innate immune responses. Drawing
on major recent advances in the field of innate immunity and cell biology, CEMIR's
research program will detail the molecular and cell biological principles for initiarion and
regulation of inflammatory responses through the use ofbasic research,
ill vitro-
and
in vivo
models and unique biobanks.
lnflammation is a host response that is triggered by noxious stimuli arising during infection
and tissue injury. The recent discoveries !hat several families of pattern recognition
receptors (PRRs) directly sense inflammatory stimuli and activate innate immune cells have
greatly increased aur molecular understanding of inflammatory diseases. A controlled
inflammatory response is needed to fight infections and to heal wounds, but it can become
detrimental
if
it is dysregulated. A plethora
of
investigations have revealed associations
New
prnciples
for
onruatoon
and regulation ofPattem
Recognitoon Reæp(or
signahng
Dlseaæ models or
inflammation:
Cardoovascular
dtsease
lnflanvnatory
bowetdosease
Bone destrudion
between chronic inflammation and a
vast number of pathologies, including
obesity,
cancer,
cardiovascular
disease (CVD). diabetes, Alzheimer's
disease, inflammatory bowel disease
(IBD) and others. The emerging
question is how the inflammatory
response is closely associated with
so many different diseases that
represent major global health
problems. Given the similar underlying pathology, prospective therapeutic targets could be
shared in various diseases. We hypothesize that the key to tind new therapeutic targets for
inflammatory diseases is tound in the very early phase of the inflammatory response where
stimulators are produced by microbes, or host cells, and are detected by PRRs. Several
recent publications give support for this
hypo:hesisand one example is the PRR called
NLRP3 that is implicated in atherosclerosis Alzheimer's disease type Il diabetes and obesity
Thus, PRRs represent exciting targets for novel, specific anti-inflammatory drugs !hal may
result in better therapies for many acute and chronic inflammatory diseases. The aim of
CEMIR is to carry out directed and detailed research on how the pattern recognition
receptors initiate and regulate inflammatory r esponses and apply this new knowledge
in disease models to identify new therapeutic targets and diagnostic tools for
inflammatory diseases. The aim is achieved by bringing together and integrating in a
Centre the complementary research of internationally leading scientists that have contributed
to three interconnected research fields:
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