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Bringing together in one Centre the expertise on basic PRR responses, intracellular
trafficking and autophagy will facilitate innovative research on how these processes are
connected in regulating inflammation, and provide significant insight into common underlying
mechanisms of inflammatory disorders. Tlle localization of CEMIR in an integrated
University hospital environment will facilitate translational research on human disease
models through collaboration w ith clinical research groups and use of available
b iobanks.
Objectives
• ldentify key vesicle transport components that regulate PRR- and adapter trafficking and
signaling from endosomes and phagosomes
• Establish the molecular basis for inflammasome activation in innate immune cells
• Decipher the mechanism by which cholesterol initiates and regulates PRR signaling
• Define the interplay between oxidative stress, PRR signaling and autophagy
• lnvestigate the roles of PRR ligands and signaling mechanisms in diseases, applying
large and well-characterized biobanks from patients with cardiovascular disease,
inflammatory bowel disease and bone dastruction with the purpose of finding common
disease mechanisms.
In order to meet these objectives, the CEMIR workplan will employ a discovery strategy that
integrates 5 research themes that cover vesicle transporters. inflammasomes, autophagy
responses, manipulation of cholesterol content in cells, and biobanks of inflammatory
diseases. We will use advanced cell biological methods to identify new principles for
initiation and regulation of PRR signaling. We are in a unique position to carry out !hese
experiments since our investigators are in the forefront of the innate immune cell biology field
with complementary expertise and insight needed to successfully carry out the objectives
outlined in this proposal. The new knowledge on PRR signaling and regulation is applied on
well-defined biobank samples. We claim that our discovery strategy is focused and contains
original approaches to the study of inflammatory responses that should lead to identification
of new therapeutic targets and diagnostic tools.
New ways for sharing frequencies- everybody having their own
base station?
Foredrag på NTVA-møte i Os lo 24. september 2013
Torleiv Maseng, f orskningssjef, Forsvarets forskningsinstitutt
The time to wait for an HD video to be downloaded should be very short and therefore the
desire for more bitrate, endless. Optical fibres to the home will offer massive bitrates and the
local access speed just limited by electronics. getting faster all the time. Therefore the future
looks bright There is one problem though, tihe radio bandwidth is limited and already fully
occupied by radio, TV, mobile phone systems etc. This will limit the services of new radio
devices in terms of responsiveness and performance unless a solution to the "lack of
bandwidth problem" is found.
To solve this problem, there seems be a unamimous agreement that new radio services need
to share the band of other existing services, like for example the TV band must also be used
by others (white space).
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